The final season of the anime is centered around helping a trans girl get away from her terrible family so it's not all lost.

The girl with the wish magic powers? Somehow I either missed that she was trans or forgot about it, though my memory of that season is pretty hazy because I both had sort of mentally checked out after slogging through the chimera ants arc in a couple of days and because I switched from the dub to the sub partway through because the dub was something like five or six episodes behind at the time.