314
Chrulemium
(lemmy.blahaj.zone)
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Its hard to answer without knowing what your app needs to do.
For a generic crossplatform program, I would say QT or GTK when programming in C/++.
Also depends on the language being used. Even if it's javascript, you could use something like Tauri or Neutralino, which can also make an executable bundle which uses the OS's native HTML renderer, no bundled chromium needed.
Some languages + recommended graphical frameworks: