this post was submitted on 25 Feb 2026
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Should I start progesterone right away? (piefed.blahaj.zone)
submitted 1 day ago by compostgoblin@piefed.blahaj.zone to c/mtf@lemmy.blahaj.zone
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I’m finally getting my hormones! I’m gonna do injections, and my doctor said she’s comfortable prescribing me oral progesterone as well if I want it. And it’s a female hormone, so why shouldn’t I have it, right? I know it’s supposed to help with breast development, and maybe libido, but I haven’t done as much reading about progesterone as I have estrogen. Should I start it at the same time I start estrogen? Is it even worth taking? Would love to hear others’ thoughts and experiences

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[–] ruben@lemmy.blahaj.zone 5 points 1 day ago (1 children)

absolutely not. prog only after breast development has finished. https://groups.io/g/MTFHRT/wiki/29602#Myths-and-what-not-to-do

[–] GeneralVincent@lemmy.world 8 points 23 hours ago* (last edited 23 hours ago)

I'm not sure that's the best source. I don't see any links to sources for the progesterone claims, and there's a bunch of fear mongering regarding doctors and official medical advice. Like

Don't give a vial into the hands of a doctor, he'd destroy it. Doctors are jealous.

and

Medical professionals routinely make mistakes in both directions: approve crazy people and unnecessarily delay transsexuals who'll not regret.

and

Endos are used to such approach, it keeps them busy and paid. With the only goal to maximize quantity of doctor visits paid by patients or insurance, gangs of American endos write guidelines how to treat transsexuals: with same approach. All the numbers in such guidelines and all the bogeyman stories about side effects of estradiol are bullshit. "Normal range" is from measurements of 90% of healthy people: 5% of lowest and 5% of highest results are discounted. Normal range of estradiol for pregnancy is up to 40000 pg/ml = 147000 pmol/l. In a group of 86 pregnant women estradiol level was up to 75137 pg/ml = 275753 pmol/l: http://cebp.aacrjournals.org/content/12/5/452.figures-only. Pregnant women don't drop dead from such estradiol level, so you wouldn't even if your peak reaches 5000 pg/ml. It's even darker than that: the numbers in guidelines are chosen deliberately low to force transsexuals to pay for more doctor visits to beg for more estradiol. Doctors also recall the mantra in their gospels (textbooks) about estrogens: dosage the less the better, stop as soon as possible. They never realize that this mantra was written in the fear of uterine cancer. And that you haven't an uterus.

I appreciate the link to source here at least, but I think the logic is flawed and not the best advice. I totally get assuaging fears of estradiol overdose, but peak estradiol isn't the same as sustained, long term elevated levels.

Also, saying there's no evidence for low dose methods-

So they claim that it's allegedly better. Doctors in other countries parrot that. There isn't any evidence. People repeat doctors' claims.

-but then advocating for higher dose with no research evidence seems like hypocrisy to me