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MSI's $80 AMD motherboards with DDR4 support swoop in to rescue gamers amid the global RAM crisis
(www.tomshardware.com)
This is a most excellent place for technology news and articles.
My understanding is that the RAM architecture is built around insanely quick read write access but doesn't really store data for more than three or four seconds at a time. Most modern programs expect the RAM to hold on to the data for basically however long they need until they access it. So most programs just won't fit into memory configured like that, and I think it's a hardware thing, not something you can change with software.