Low and zero gravity can affect how roots spread/dig and later can cause issues with how water and nutrients circulate through the stalk since they evolved to circulate with Earth level gravity. Space station experiments have proven it’s not impossible, the plants can adapt, they’re just a bit different. Trees would probably struggle, most crops would be fine. What’s really difficult is pollination. You’d probably have to hand pollinate, set up a wind system in your greenhouse, or get self-pollinaters. Bees would struggle to adapt because low gravity would mess with their flight, their dance communication, and probably their honeycomb structure and larval development.