I use a AirBnB if:

1. I'm bringing my dog. A house with a fenced yard beats a hotel for that hands down every time.
2. Using the house is a major feature of the vacation. We live in an apartment in a city so sometimes it's nice to just spend a week in a cabin in the mountains or a long weekend at a house with a pool.
3. I'm traveling with a group and I actually want to spend time with those people. It's nice to have a private social space that isn't someone's bedroom.

I prefer hotels if:

1. I'm traveling solo. If I'm not renting a whole house, I want the hotel amenities. Plusi can pretend to be a bachelor again and act like a slob.
2. I have an action packed trip planned. Every time I've been to Vegas I was pretty much only in my room to shower or sleep.
3. I'm traveling with a group and know I'll need some personal space.