Yes, 100%.

One of the challenges will be getting order information from the buyer to the seller in a way that is consistent and error-free. Item numbers, unit prices, shipping, tax, total due. Without a shopping cart application, sellers might be best served by bundling shipping and tax into the item price. Alternatively, gopher commerce could make use of a purchase order/invoice pattern. That's a bit more work for everyone, but should reduce miscommunication.