I'd love to see Monkey Island revived as a more open-world style game on the order of Fallout.

Dirty Bomb

Arc the Lad in the art of the originals set after III. To be clear, Twilight of the Spirits would still be canon, but it's also 1,000 years in the future.

Tokyo Xtreme Racer

And thankfully, they just released a teaser for a new one so I guess my wish is going to be granted!

Cyberstadium Series: Basewars.

Sure, it was only 1 game, so maybe not a series, but as the name suggests, it was meant to be a series.

I'd really like to see another time-based drama similar to The Last Express. It had a lot of time-based events where you could run into particular passengers of the train in the hallways, and gained a strong sense of physical "presence" as people pushed past you in the halls using detailed rotoscope animations.

The Invisible Hours comes close - it's non-interactive, basically letting you play as a ghost cameraman watching the mystery.

Dark Cloudy, but it should be built around city building a bit more than combat

I mean, I don’t think it ever really became a series, but I’d love to see a modern remastering of The Suffering

CyberMage: Darklight Awakening

Zork

Strange Adventures in Infinite Space