Ukraine

You could use centrifuges, but there are larger fundamental issues, like the cost of moving the mass of a refinery and inputs into space and deorbiting the outputs. The vulnerability of space launch infrastructure itself. Probably heat dissipation, though I'm not gonna go look up specifics.

Just the time to develop, manufacture and deploy something like that compared to the kind of timeline permitted by war.

I mean, I assume that Russian dude isn't trying to do a deep analysis here, just throw out encouraging outside-the-box ideas, but even with that for context, "space" is pretty bonkers.

EDIT: Oh, saw the bit about shooting things down before they take off. Just gallows humor.