Metroid: Fusion is pretty fun!

The Longest Journey, Dreamfall, Dreamfall Chapters

I enjoyed the chill, stylized vibes in Sable. Coming of age, botw-inspired exploration, beautiful world. No (?)Combat—I don’t remember fully, but very little at least. Just explore, experiment, and engage the world around you. A passable world-build/story too!

By NOLF you mean No One Lives Forever? If so a quick search gave me this "revival" site, seeing the Windows targets i bet that runs on Wine

Resident Evil 5.

Sheva is a badass.

Play Gris, if for no other reason than the art. It's just so beautiful.

Extremely retro, but currently available on the Mac App Store: Mess O' Trouble. It was a WorldBuilder game--think Infocom, but with static pictures you could interact with. I believe your choice of Daredevil Dawn or Fearless Frank had some impact on the gameplay if you got far enough, but child me never did.

Passing By (I think Curly is technically gender-neutral but I always saw her as a girl).

I think the download files got taken down though unfortunately

Edit: Apparantly they've been canonically made non-binary

Gravity Rush

there's a demo for a game on steam called Laika: Aged Through Blood which has a badass motorcycle mom

If you're into farming and dungeon delving, Rune Factory 4 has a female protagonist option.

Played Sakuna: Of Rice and Ruin recently

fantastic game. The platforming is fun with surprising depth. The Rice mechanics have way more depth than I can stand, but it's still forgiving enough that you never feel severely punished for messing up.