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submitted 1 year ago by USAONE@lemmy.world to c/world@lemmy.world
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[-] MyPornAlt@lemmynsfw.com 88 points 1 year ago* (last edited 1 year ago)

Meth is an approved drug for the treatment of ADHD.

It’s schedule II, while marijuana is schedule I, it’s crazy.

[-] BarrelAgedBoredom@lemm.ee 23 points 1 year ago* (last edited 1 year ago)

Not to mention the pharmacological effects of methamphetamine are indistinguishable from Adderall when taken orally in similar doses

E: I was misremembering this study. It was measuring the physiological and behavioral effects of insufflated amphetamines, not oral. Here's a vice article with additional info from the doctor who conducted the study

[-] circuscritic@lemmy.ca 25 points 1 year ago* (last edited 1 year ago)

This is objectively false.

Setting aside the issue of QA and how and in what conditions this methamphetamine is being produced, no, the pharmacological effects of methamphetamine are NOT just the same as Adderall (blend of 4 different amphetamine salts).

It's also not prescribed for ADHD, except in rare circumstances. It's mostly prescribed for conditions like narcolepsy, because it's significantly more psychoactive then amphetamine salts, and that's BEFORE you factor in issue of these being cartel produced counterfeit pressed meth pills vs production in an actual pharmaceutical laboratory with the accompanying conditions and controls.

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[-] banneryear1868@lemmy.world 10 points 1 year ago* (last edited 1 year ago)

I can vouch for this as someone who's tried equivalent doses of each, less methamphetamine is required to achieve the same effects but I couldn't tell the difference. Compared with the recreational forms you're also dealing with different salts combined in the prescription. This sentiment is also common.

[-] Corkyskog@sh.itjust.works 5 points 1 year ago

I think you mean equivalent dose? Isn't meth like nearly 50% stronger?

[-] BarrelAgedBoredom@lemm.ee 6 points 1 year ago

Turns out I was misremembering a study I read a few years back. It was intranasal, not oral. They're still incredibly similar in their effects at the same dose. Here's the study. And a vice article about the study with commentary from the doctor who conducted it.

[-] Shard@lemmy.world 1 points 1 year ago

Upvote for coming back to correct a mistake

[-] CalamityBalls@kbin.social 2 points 1 year ago

A range of amphetamine compounds are approved for the treatment of ADHD.
Methamphetamine, what people generally talk about when they say meth, is not.

[-] superduperenigma@lemmy.world 33 points 1 year ago* (last edited 1 year ago)

Desoxyn is an FDA approved brand-name methamphetamine that is prescribed to treat ADHD and obesity. It's not very common, and usually ADHD patients will be prescribed some other amphetamine, but meth is schedule II and it is used to treat ADHD in some cases.

https://www.dea.gov/sites/default/files/2020-06/Methamphetamine-2020_0.pdf

[-] banneryear1868@lemmy.world 9 points 1 year ago* (last edited 1 year ago)

Multiple commenters say Desoxyn isn't '"common" but at the pharmacy I worked at for 5 years we always stocked it, and had enough scripts coming in that we'd need to make sure we had inventory. This was for adhd mostly. Methamphetamine is more potent per molecule so it's not necessarily analogous with amphetamine for side effects.

[-] superduperenigma@lemmy.world 1 points 1 year ago

Interesting. To be honest, I was basing that primarily on my own anecdotal experiences. Everyone I know whose gotten a prescription for one for some other amphetamine.

[-] ale@lemmy.world 12 points 1 year ago

From another comment in this thread, at least in the US, it looks like it actually is approved for treatment of ADHD. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/005378s028lbl.pdf

[-] circuscritic@lemmy.ca 4 points 1 year ago

It is, but it's very rare. It's mostly used for issues like narcolepsy, as it's significantly more stimulating then amphetamine salts.

[-] unconfirmedsourcesDOTgov 1 points 1 year ago

Y'know, my initial thought was to refute your claim, but when I looked into it, turns out you're right, mostly. While I'm dubious that meth is approved for treatment of adhd, it is indeed listed as a schedule 2 substance, while cannabis is still schedule 1. Wild!

[-] poszod@lemmy.world 61 points 1 year ago

Oh no that's terrible. Which pharmacies are doing that so I know the ones to avoid?

[-] cheese_greater@lemmy.world 33 points 1 year ago* (last edited 1 year ago)

Sounds disgusting, but Which ONES, which ONES?

I call BS unless I get a source

[-] cheese_greater@lemmy.world 4 points 1 year ago

Clever girl

[-] Got_Bent@lemmy.world 27 points 1 year ago* (last edited 1 year ago)

Do these pharmacies by chance serve fried chicken or offer commercial laundry services?

[-] ale@lemmy.world 17 points 1 year ago

Isn't Adderall basically meth? Is there a difference in how they would affect ADHD symptoms at low dose?

[-] cheese_greater@lemmy.world 27 points 1 year ago* (last edited 1 year ago)

Its similar but the additional methyl group makes it more potent.

Kinda like a morphine (Adderall) vs heroin (meth)

[-] GiveMemes@jlai.lu 33 points 1 year ago* (last edited 1 year ago)

This is not true. The extra methyl group makes it cross the blood brain barrier faster. The extra potency is from the drug itself being different from dexampphetamine, the active ingredient in adderall, however it is important to note that at doses below 50 mg methamphetamine and 100mg adderall, effects are almost entirely the same, with the serotoninergic (is this a word ?) aspects of meth only coming from high doses.

Do not recommend either.

[-] cheese_greater@lemmy.world 17 points 1 year ago* (last edited 1 year ago)

If something hits harder and faster, I'm pretty sure definitionally its more potent.

Potency is a function of its effect relative to the amount used. Like this is more of "yes, AND" type deal, I'm not wrong and you're right to elaborate that this is due to its increased abillity to permeate BBB

different from dextroamphetamine

Unless we're getting into racemics , I'm saying its basically amphetamine + methyl group, lets not get so granular here

Also, meth and amphetamine can be taken such that the doses are equipotent, it would just be less meth and more amphetamine by weight/dosage (all other things like ROA and context being equal)

Re:Serotonin: I believe amphet and meth both affect serotonin dose dependant but I dont think there's any way to say only meth also implicates serotonergic release or transmission

[-] DrBob@lemmy.ca 7 points 1 year ago

Thank you! I'm normally the crank making this comment. Also don't forget for the heroin example that the acetyl groups get cleaved after crossing the BBB so it goes back to being regular ol' morphine before it can bind to a receptor.

[-] banneryear1868@lemmy.world 1 points 1 year ago

Serotonergic which is minor in high amphetamine doses, they're more dopaminergic. Serotonin is more SSRIs and psychedelics.

[-] fne8w2ah@lemmy.world 9 points 1 year ago

Did they mean methylphenidate?

[-] irdc@derp.foo 8 points 1 year ago

That sounds like uncontrolled dosages of Desoxyn.

[-] SendMePhotos@lemmy.world 2 points 1 year ago
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this post was submitted on 21 Dec 2023
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