this post was submitted on 14 May 2026
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Today I Learned

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"inflammation is now understood to be a key mediator of OA that contributes to cartilage loss and progressive degeneration of affected joints... OA is no longer considered a noninflammatory arthritis or a 'wear and tear' disease"

I heretofore thought age-related cartilage loss was the cause of osteoarthritis and inflammation. Turns out it's the other way around: the inflammation degrades cartilage. Okay, no more slogging through joint pains for me, regardless of how small.

Edit: added a phrase for clarity

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[–] altphoto@lemmy.today 4 points 17 hours ago

My mom has RA. She takes all sorts of meds for it.

I think I'll be getting it too. When I heat my hands like when I weld or wash dishes in hot water I get joint pain. Lately I've been getting random hives and didn't know what it was until I took a simple antihistamine. Maybe there's a connection between the inflammation from allergic reactions to RA.

I think I improved my situation by going began. No meat's of any kind. And I'm also eliminating bread from my diet. I think bread is one of the causes of my stomach discomfort. I'm using Lactobacillus Reuteri yoghurt to eliminate undesirable stomach Bacteria. I think that's also helping me reduce my inflammation.

[–] core@leminal.space 5 points 19 hours ago

So my knees sounding like rice krispies when going up stairs isn't a good thing?

[–] LincolnsDogFido@lemmy.zip 9 points 2 days ago (3 children)

This is a field I study. Its more complicated than yes/no. OA is caused by inflammation. However, inflammation when introduced into a joint space raises the friction coefficient between surfaces within the joint. More friction leads to mechanical stress and deterioration.

The friction coefficient for synovial joints ranges from 0.0015 - 0.01 depending on the study. Essentially frictionless. That's why when inflammation enters the synovial fluid, you hear crepitus or "creaking". Friction goes up and tendons vibrate like strings on a violin. For reference, ice on a Teflon pan has a friction coefficient of 0.05 - 0.10. Roughly ×5 the conservative estimate for synovial joints.

[–] fiat_lux@lemmy.zip 3 points 1 day ago (1 children)

So when people told me as a kid not to worry about my crepitus, they were in fact completely wrong? If so, I'm feeling vindicated but also sore, but that's better than only sore.

[–] LincolnsDogFido@lemmy.zip 4 points 1 day ago (1 children)

Well, I guess it depends entirely on what you could do about it. If the crepitus was brought about by chronic malmechanics then yes. If it was hereditarily driven then there's nothing you could do about it. Typically, I preach to my patients that popping, clicking, snapping, etc. are only notable if they induce pain or if they were brought about by a change in activity.

A secondary note on pain is that it's part of the human condition. Pain is relative and inevitable. If you live your life in a bubble then a sprained ankle is going to feel like a gunshot wound. There will always be some form pain or soreness. The trick is to address it as it comes about and shift it to the next weakest link in the chain. If you have low back pain, strengthen your core to treat it. Then that pain may shift to your hips where you have overactive or weak abductors, then it may be your neck. Who knows. But there's few things as debilitating as chronic pain in one location. The more painful it gets, the less you'll want to use it and you end up building a positive feedback loop.

[–] fiat_lux@lemmy.zip 3 points 1 day ago

Fair. In my case I wish someone had not overlooked the systemic inflammation (from a different condition that has been recently correlated with OA, somewhat unexpectedly) and the malmechanics I was experiencing, so that I might have avoided some of the further issues, but, so it goes.

I manage to shift some of the chronic pain, but sadly society really likes to build worlds that have only one blessed way of doing certain things, which makes it impossible to shift more consistently. So I will have to mostly content myself with smugly sore.

Given you appear to be a doctor though, I do have one favor to ask. If you ever get a flexible kid with crepitus come through your doors, maybe add a CRP test to their blood work, just on the off-chance and even if only for the chain of evidence.

[–] lefty7283@lemmy.world 3 points 2 days ago

Had the chance to do cadaver dissections and synovial fluid is some fascinating stuff! Slightly mucusy, but incredibly slick

[–] metalaco@lemmy.world 1 points 2 days ago

Fascinating!!!

[–] yenahmik@lemmy.world 6 points 2 days ago

Me reading this while rubbing my chronically sore knees from sports training...

[–] xep@discuss.online 7 points 2 days ago (2 children)

When I started on a low inflammation elimination diet it did wonders for my joint pain. Can recommend.

[–] teyrnon@sh.itjust.works 3 points 2 days ago (1 children)

May I ask what a low inflammation diet is? Wild Mexican yams? I say that because yams have corticosteroid precursors in them, they first created corticosteroids from Mexican wild yams and that is the go-to treatment for inflammation.

[–] ryannathans@aussie.zone 6 points 2 days ago (1 children)

In short, no processed foods or highly refined oils

[–] xep@discuss.online 0 points 2 days ago (1 children)

I took that a step further and eat only beef, salt, and water, but if you figure out what causes the inflammation you don't have to go this far.

[–] MalReynolds@slrpnk.net 1 points 1 day ago

Same, tried the AID diet first without significant effect. Two weeks of beef salt water got me there and I started identifying foods ([chicken] eggs and [cow] cheese being worst, but carbs being problematic in general, hence AID failure). I now do it yearly after Christmas to check foods I'm suspicious of. It's extreme, but pretty much guaranteed to work, barring Lyme disease, basically no-one has an inflammatory reaction to beef.

For those of you contemplating this, trick I found is when I eat an inflammatory food while hydrating properly I put on a Kg + of water weight within 24 hours (remember, inflammation of an injury makes it swell, with water). Easy to measure.

[–] ryannathans@aussie.zone 2 points 2 days ago

This.

Have met people in the coeliac community that had their arthritis go away entirely after strictly stopping gluten

[–] teyrnon@sh.itjust.works 2 points 2 days ago

It has long been known that certain bacterial infections like strep can cause horrible debilitating pain in your joints, most common I believe like knees and stuff, but other people like shoulders and elbows. Not just strep though.

They treat it with cortico steroids, which are bad to take in high doses for long periods of time, which this is. Very very bad. Perhaps not as bad as horrible debilitating chronic pain.

[–] digitalFatteh@lemmy.ca 1 points 2 days ago

My back and knees tingle reading this. Just waiting on the knee cortisone inflammation to ease off 😉

[–] Reyali@lemmy.world 1 points 2 days ago* (last edited 2 days ago) (3 children)

Here I am staring at my sausage-like thumb that’s been swollen like this for three days thanks to rheumatoid arthritis. This article gives good context for why RA often results in OA at a younger age. Maybe I will go take a prednisone and apply another dose of diclofenac to try to knock this inflammation down…

[–] jet@hackertalks.com 2 points 1 day ago

If you haven't tried one yet, you might want to consider a elimination diet protocol for a few weeks. If your RA is exacerbated by some food compound it would reveal itself, and you could then plan your meals avoiding that.

I've seen lots of consistent anecdotes, and myself, diminishing joint pain and inflammation on a strict elimination diet.

[–] roofuskit@lemmy.world 2 points 2 days ago (1 children)

There have been some good medications for RA created in the last decade or so. Has your rheumatologist prescribed anything longer term than prednisone? Prednisone is not really a long term safe solution.

[–] Reyali@lemmy.world 3 points 2 days ago

Prednisone is my rescue medication for flares, not my normal treatment. Hence why I thought I might take it just today.

I’m on two meds, one that came out in 2019. I’ve been diagnosed for a year this month, and I have cycled through five or so drugs to finally land on a combo that actually controls the pain. The current inflammation is unlike what I’ve experienced regularly before, in that it is purely swelling with no pain, but I also have a reasonable theory as to the cause. I plan to bring it up at my next appointment regardless.

[–] JayleneSlide@lemmy.world 2 points 2 days ago (3 children)

RA... oof. That shit is a curse*, a giant FU from the universe. I hope you get the relief/management you need. Tangential: does the prednisone get you all hyper?

*My aunt had it. In my pre-teens, my mother sent me to live with and care for her in final years (it wasn't the RA that got her), so I deeply empathize with your health struggles.

[–] Reyali@lemmy.world 2 points 1 day ago (1 children)

Thankfully an RA diagnosis today is extremely different than one even 20 years ago, and I’ve only had it since the start of 2025. There are a lot of good options for meds, and there are some very promising long-term treatments on the horizon.

If actuarial tables estimate correctly, I’ll have around 40 years to live with this shit. My hope is for a cure before that happens (there has been enough advancement in autoimmune treatment even in just the last 5 years that it’s not a total pipe dream).

All that said, after spending most of 2025 with intolerable pain in my hands, I know if something prevents me from getting treatment long-term (like a societal collapse, not like pharmacy challenges), I expect I would find a way to …opt out. I was losing my mind until I found treatment that works (at least most of the time… this week is thankfully the exception now).

As for prednisone, I have extremely few side effects from it and no hyperactivity at all. I took it often from my diagnosis last May through this January. The first time was doses from 2.5–30 mg a day (normally 10–15) for most of 3 months straight. I had zero complaints while on it; however, upon stopping I was exhausted for about three days straight. Tired to the bone kind of feeling.

I ended up back on it for another 3 months, at or below 10 mg daily and I tapered more slowly, so the tiredness was much more manageable that time.

Like another commenter said, that’s a lot to expect of a pre-teen. I’m sorry you had to see that so young.

[–] Tollana1234567@lemmy.today 1 points 1 day ago* (last edited 1 day ago) (1 children)

i think prednisone's side effect is more apparent if you are on higher doses for longer periods of time, 80-100mg per day. i took it for 2 weeks for severe atopic dermatitis, dint cause any symptoms, since it was a taper too.

for RA, you should request biologic medications, theres a couple out for them already. Likewise with people with psoriasis/psoriatic arthiritis.

[–] Reyali@lemmy.world 1 points 1 day ago

I started on biologics after diagnosis and they didn’t work for me. I am on a daily JAK inhibitor and a twice-daily NSAID and that has my pain controlled. The current swelling is something new, and is not painful.

The long-term prednisone use was to help me manage the pain while seeing if a biologic would work. It helped, but I still had to take ~15 mg of prednisone a day or I was in debilitating pain.

[–] teyrnon@sh.itjust.works 1 points 2 days ago

No rheumatoid arthritis here but took Prednisone for an issue I had for a few weeks and I did not notice any sort of hyperactivity. And most others I talked to did not either although several did.

[–] kamenlady@lemmy.world 1 points 2 days ago

In my pre-teens, my mother sent me to live with and care for her in final years

I imagine this to be no easy task for anyone, especially a pre-teen.

[–] bizarroland@lemmy.world 0 points 2 days ago* (last edited 2 days ago) (2 children)

Sounds like it might be a good idea to suggest people taking glucosamine and turmeric early.

[–] Reyali@lemmy.world 1 points 1 day ago (1 children)

Turmeric is questionable. A lot of early studies touting its benefits were published by the same person/group, and they had financial motivations behind it. Some has been straight debunked, and skepticism is a good stance to hold on it. Plus it’s been shown that turmeric supplements are a major source of lead, so the risk may outweigh the possible benefits.

[–] sashin@veganism.social 1 points 1 day ago

@Reyali @bizarroland TIL That there is no clinical evidence that turmeric offers any health benefit https://en.wikipedia.org/wiki/Turmeric?wprov=sfla1

[–] roofuskit@lemmy.world 1 points 2 days ago

Low impact exercise is a great tool for reducing inflammation. Vitamin D is also an important part of regulating your immune system. Anything that supports a healthy immune system will help regulate its response and reduce inflammation.