Chris Judge from Stargate did the same. That dude is in a lot of video games.

Kate Mulgrew was a very distinctive voice. I heard it right away in Dragon Age Origin.

Patrick Stewart also has a great voice in Elder Scrolls Oblivion.

The first person from Trek I remember hearing in a game was Leonard Nimoy in Civilization.

Star Trek actors are the most robust actors. They're everywhere. I watched all of Boston Legal without realizing it wasn't Star Trek. Our boy Frakes plays adult Finn in the adventure time episode Puoy, George plays Ricardio. You can't escape it. Star Trek encompasses all.

Edit: sort of unnecessary edit but when I use actors here it is gender neutral.

Ensign Ro and old Jake are both in Half-Life 2, those voices are ingrained in my memory so I instantly recognized them when i watched the show.

I definitely remember recognizing Frakes, Dorn, and de Lancie while playing through the War of the Chosen expansion for XCOM2. Also René Auberjonois on a few of the Uncharted games as well.

It's especially great when they do something that's completely off the walls crazy. Michael Dorn played a screaming dwarf in the Billy and Mandy episode "Here There Be Dwarves," who went mad after centuries of mushroom farming and exacted his revenge by invading the Keebler elves' hollow tree. Then R. Lee Ermey pops up to censor the carnage and the dwarves and elves compromise by making mushroom cookies, and Billy does karaoke. That show was so delightfully warped and random sometimes.

John De Lancie (Q) has done a lot of voice work, and acting for sure. My child was besides themselves when they found out he voiced Discord in MLP

Sir Patrick Stewart as the Encarta (or was it Britannica?) encyclopedia "help" narration was hilarious in how unnecessary it was.

There seem to be three distinct post-Trek futures:

• genuine big shot actor
• reasonably successful voice actor
• B-movie "star", featured prominently on the poster and appearing for 5 minutes in the actual movie.

George Takei killed it in his role in Yakuza: Like a Dragon. (Literally and figuratively, he played a hitman-come-mob boss and a father figure to the game’s protagonist.) I wish he had more screen time in the role.

Tim Russ and Robert Picardo are in Fallout 4.

Picardo does a fine job as the Institute scientist who is in charge of synth production; seemed very much like the EMH's role and he seemed to play it that way.

Russ, though... He's a Brotherhood of Steel guy on the Prydwyn and just seems like a more stern version of Tuvok. Not because the role called for it, but because he was just reading lines without any passion behind them. Or wasn't given proper direction (which given some things other VAs who worked on that have said is probably closer to the truth).

Patrick Stewart has also lent his voice to a Bethesda game as Uriel Septim in Oblivion.

Admin Shimmerman is in Starfield and I think it's great because his character there is a billionaire corpo dude which reminds me Quark.

Oh and I can't forget that William Shatner not only gave his voice to, he also literally wrote TekWars.

Don't forget Cheers actors who became Star Trek actors.