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[-] captain_oni@lemmy.world 49 points 6 months ago

A step closer on my childhood dream of becoming a street shark!

[-] uhN0id@programming.dev 17 points 6 months ago

Your dream sounds Jawsome!

[-] gearheart@lemm.ee 6 points 6 months ago* (last edited 6 months ago)

Captain shark tutu tutu tutu🎶~

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[-] Snapz@lemmy.world 43 points 6 months ago

Okay, but grow teeth WHERE?

[-] Rusty@lemmy.ca 13 points 6 months ago
[-] Daxtron2@startrek.website 6 points 6 months ago

Wherever you want, that's the beauty of a teratoma

[-] shasta@lemm.ee 4 points 6 months ago
[-] MudSkipperKisser@lemmy.world 5 points 6 months ago

As an owner of a vagina I have concerns here

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[-] Galapagon@sh.itjust.works 37 points 6 months ago

How will I threaten my child to brush their teeth now?

[-] Grimy@lemmy.world 25 points 6 months ago

Well now you can pull one out whenever it starts getting yellow and regrow it. It won't take many for him to start brushing.

[-] littlebluespark@lemmy.world 20 points 6 months ago

Jesus. 😱 How long do you think it takes to regrow a child?

[-] MystikIncarnate@lemmy.ca 5 points 6 months ago

At least 9 months. Trying to speed this up might make it slower, but it won't make it happen any quicker.

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[-] sunbrrnslapper@lemmy.world 7 points 6 months ago

Peer pressure should fix this shortly.

[-] Vytle@lemmy.world 34 points 6 months ago

This shit better be affordable and covered by health insurance.

[-] Kiosade@lemmy.ca 26 points 6 months ago

Narrator: “It won’t be.”

[-] Hugh_Jeggs@lemm.ee 22 points 6 months ago

It will be.

In civilised societies

[-] littlebluespark@lemmy.world 4 points 6 months ago

Heh. You lookin' to buy a bridge, too? I got a couple nice ones on clearance. C'mere a sec.

[-] southsamurai@sh.itjust.works 26 points 6 months ago

I do wish that media coverage would stop calling it a regrowth drug. It might get there eventually, but that's not what it is, and it causes issues with people misunderstanding medical science.

[-] bobs_monkey@lemm.ee 31 points 6 months ago* (last edited 6 months ago)

The medicine itself deactivates the uterine sensitization-associated gene-1 (USAG-1) protein, which suppresses tooth growth. As we reported in 2023, blocking USAG-1's interaction with other proteins encourages bone morphogenetic protein (BMP) signaling, which triggers new bone to generate. In the ferret study, the drug resulted in the growth of a new tooth (fourth from left), and it also strengthened bone in the existing set. It resulted in new teeth emerging in the mouths of mice and ferrets, species that share close to the same USAG-1 properties as humans.

Am I missing something? It seems like it prompts the body to actually grow new teeth, though I'll admit I am way out of my wheelhouse here.

[-] southsamurai@sh.itjust.works 11 points 6 months ago

It's more about the extremely early stages of things. It will be years before it gets to the point it's being used on people that have lost teeth. Right now, it's for people only with congenital lack of teeth.

I'm not saying the drug isn't going there eventually, it likely will. But it's not going to be even tested for other uses for something like two more years (iirc, I'm pulling this from memory over the last year or so that the drug has been reported on) from now, and even that assumes the current testing is successful.

It's an incredibly promising thing that will help a lot of people if it's safe and effective, not just the current targeted population.

I'm actually hyped for this to work out. My working life was partially with geriatric patients. The quality of life loss that goes along with tooth loss is horrible. Then there's the loss of bone density in the jaw after losing the teeth.

My peeve is with the reporting putting the cart before the horse. Bad medical reporting causes problems even more than bad science reporting in general. Report what is, especially in headlines, then cover what might be as a secondary note. Right now, regrowing teeth is not proven capability of the drug for humans. The testing for growing teeth where they've never been hasn't even finished yet.

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[-] Dozzi92@lemmy.world 5 points 6 months ago* (last edited 6 months ago)

What is it? I guess the distinction is between regrowth and regeneration. I'll admit regrowth sounded great, because my four front teeth have been shaved down to posts for veneers because of an unfortunate incident with a hockey puck. Sounds like this isn't for me.

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[-] Jomega@lemmy.world 19 points 6 months ago
[-] Varyk@sh.itjust.works 18 points 6 months ago

I have been looking forward to this for 2 decades.

Every dentist I've ever been to has told me that they didn't know when research would be progressing on actual regrowth.

Finally, we're in the maybe soon stage.

Hope the trials go well.

[-] TwinTusks@bitforged.space 8 points 6 months ago

as early as 2030

You might still have another decade waiting.

[-] Varyk@sh.itjust.works 17 points 6 months ago

5 and a half years beat 20, and I am patient. And hopefully a patient.

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[-] Kolanaki@yiffit.net 17 points 6 months ago* (last edited 6 months ago)

"It appears the drug may be too effective. The test patients have had to start chewing on things to keep their teeth from growing through their own skull."

"Bob, we're still testing it on mice..."

[-] weariedfae@lemmy.world 16 points 6 months ago

Trials are set to include only adult males at first, then children at later rounds. That's not ideal.

I'm super pumped about the prospect of regrowing teeth though!

[-] Chee_Koala@lemmy.world 23 points 6 months ago* (last edited 6 months ago)

Often times people assigned female at birth are excluded from these kinds of medical trials because the female cycle can affect the measurements so much, which can distort the outcome. Still sucks but there's at least medical dispensation to discriminate.

Source: I was excluded from some paid medical test on some grounds and I had a conversation about reasons for exclusions with the people that were rejecting my application :-)

[-] hydroptic@sopuli.xyz 17 points 6 months ago

Yep, and then doctors and researchers go all surprised Pikachu face when it turns out that eg. some pain medication doesn't work as well on women, but naturally this conclusion is only arrived at after decades of insisting that they should work and that you're just being an irrational hysterical feeeeemale if you say they don't

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[-] BarbecueCowboy@lemmy.world 12 points 6 months ago

Last I heard about this drug, it was focused on people who were missing teeth from birth / due to congenital defects, may work still but not yet applicable to regrowing teeth unfortunately.

[-] NegativeLookBehind@lemmy.world 14 points 6 months ago* (last edited 6 months ago)

Side effects include:

  • mutated anus

  • disappearing retinas

  • sudden bone splintering

  • genital duplication

  • having too many god damned teeth

[-] TheEEEdiot@sh.itjust.works 14 points 6 months ago

I'll take genital duplication if I have to choose one of those.

[-] Infynis@midwest.social 10 points 6 months ago

Hold on, I'm going to need the specifics on that anus mutation before I decide

[-] NegativeLookBehind@lemmy.world 10 points 6 months ago* (last edited 6 months ago)

We’ve seen a large number of subjects form functional tastebuds on their sphincters.

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[-] NegativeLookBehind@lemmy.world 8 points 6 months ago

In our clinical trials, the secondary genitalia usually manifests itself on a subjects forehead.

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[-] z00s@lemmy.world 14 points 6 months ago

Ok but how will they ensure the right teeth get regrown? Imagine waking up to find that your impacted wisdom teeth that you had removed a decade ago had come back

[-] Kolanaki@yiffit.net 4 points 6 months ago* (last edited 6 months ago)

Dentists that specialize in wisdom tooth extraction: 🤑🤑🤑

[-] p5yk0t1km1r4ge@lemmy.world 12 points 6 months ago* (last edited 6 months ago)

[2026]

The dark sky fractures with a thunderous might. Chris and Jane melt into the darkness and slink behind an abandoned cafe. They hear nothing but distant clicking beneath each thunderous bellow ahead. Jane sobs. Chris gives her a warm embrace. He speaks with a vague whisper, "We will be OK, honey. Let's just stick to the plan." Against her will, she let's out a slightly louder sob, then gasps at what she just did. The chattering stops. Her heart pounds. Lightning strikes, and they see it: the abomination had no visible face, just teeth. Decayed teeth against rotting skin. It faces their direction before letting out a terrifying hiss as it dashes towards them, its head split open like a Venus fly trap, revealing a terrifying set of venomous fangs. Chris forcefully grabs her arm, and they run in a panic as several more abominations begin to chase after them. One foot in front of the other. Scan for a clear path. Watch out for obstacles. Find somewhere out of sight, and hide. Be as quiet as possible. Just like the training manual said. Chris desperately looks ahead as his breathing turns shallow; then, his stomach sinks as they come to a chain link fence overlooking a sea of these monsters choking the streets. They were trapped on both sides, and he had to think fast. He spots an open door, and they run for it. He slams it shut, and they begin looking for a hiding place. It appeared to be a break room of sorts; they began making their way past dozens of upturned tables and chairs, finding purchase in a small janitorial closet. "It's going to be alright, sweetheart. Remember what the CDC said, we need to lie low and wait. They only respond to noise." She didn't respond. Quietly, they sit, waiting to be passed over. Strange, erratic breathing fills the closet, and Chris whispers. "Jane, are you okay?" chattering. In a panic, he turns and sees that her face is now deformed with hundreds of teeth. Her head splits open, and with a horrific roar, she lunges at him, and things go black.

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[-] Mango@lemmy.world 8 points 6 months ago

I'm a human! Pick me!

[-] gearheart@lemm.ee 7 points 6 months ago

Teeth (2007) : "soon..."

[-] TheHottub@lemmy.world 7 points 6 months ago

Interesting. How do you just grow the one tooth and not all teeth?

[-] Wilzax@lemmy.world 13 points 6 months ago

Tooth seeds

[-] TheHottub@lemmy.world 5 points 6 months ago

Looks like not having the tooth there triggers it to grow a new one.

[-] XTL@sopuli.xyz 4 points 6 months ago

That sounds like an awfully broad target.

[-] TheHottub@lemmy.world 3 points 6 months ago

Agreed. When I was a kid I have to have an extra tooth removed from the roof of my mouth. I wonder if it would grow back?

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[-] mosscap@slrpnk.net 4 points 6 months ago

This is awesome!

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this post was submitted on 03 Jun 2024
447 points (99.1% liked)

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