Inanna/Ishtar, also called "The Queen of Heaven", is an ancient Mesopotamian goddess of love, war, and fertility, but also associated with gender, sexuality, political power, and divine justice. She was originally known in Ancient Sumer as Inanna, and later worshipped by Assyrians, Akkadians, and Babylonians as Ishtar. She is also widely seen as a progenitor to the goddesses Venus/Aphrodite. She tends to be associated with lions and sometimes owls. Her symbol is an 8-pointed star that looks something like this:

Her most popular myth involves her descent into the underworld, which was ruled by her sister, Erishkigal. Inanna went there with the purpose of attending the funeral of her sister's husband Gugulanna, who was slain by Gilgamesh, but her trip was also potentially motivated by an intent to expand her dominion over the underworld. Upon reaching her sister's throne room, seven underworld judges (known as the Annuna) blamed her for the death of Gugulanna, and so Erishkigal killed her and hung her body on a hook. Days later, Enki hears of her death and sends two enby friends, the kurgarr and the kalatar (described as being neither male nor female) to save her. They sprinkle the food and water of life on her corpse, bringing her back to life. The enby friends escort her out, but the guardians of the underworld kidnap her husband Dumuzid to serve as her replacement. Dumuzid is later allowed to return to heaven for half the year, being replaced by his sister Geshintanna, which serves as an explanation for the changing of the seasons throughout the year.
The priesthood of Inanna's cult was known as the Gala, a group widely known for transcending gender boundaries and were said to have sung in the women's dialect, adopted women's names, and wore attire traditionally used by both men and women. They would also often perform war dances in women's attire in her temples, and festivals in her honor were typically marked by crossdressing and the general blurring of gender lines. They were also well-respected community members who took it upon themselves to look after the sick, poor, and downtrodden.

Inanna was also said to have the divine power to change a person's gender directly. Enheduanna's hymn states:
To open up roads and paths, a place of peace for the journey, a companion for the weak, are yours, Inanna. To keep paths and ways in good order, to shatter earth and to make it firm are yours, Inanna. To destroy, to create, to tear out, and to establish are yours, Inanna. To turn a man into a woman and a woman into a man are yours, Inanna.
If you'd like to read more about Inanna/Ishtar and her associations with gender, this is a good article worth reading. There's also this video about Inanna and this video about the Gala specifically.
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