Steve Buscemi

Ron Perlman, I mostly enjoy that most Maine coon cats look more like him than he does somehow.

Willem Dafoe

I dunno about "weird", what with that being pretty vague.

But, Natalie Dormer is well known for having an asymmetrical face.

You've got Kristen Schaal that's got unusual proportions.

Kate Micucci is similarly distinct.

Tilda Swinton has to be on the list, and is probably the most famous of the atypically beautiful actresses out there.

Mayim Bialik (or however the fuck you spell her last name) is fairly atypical for an actress.

Rachel Dratch from SNL is a contender. Hell, for that matter, Ana Gasteyer, Tina Fey, Molly Shannon, Cheri O'Teri, and Gilda Radner are all fairly unique looking and not the typical Hollywood type of beauty. You could essentially throw a dart at a list of SNL alums and hit someone with distinct features.

Shit, Uma Thurman is definitely not the old Hollywood type of beauty.

Then you've got Bjork, who kinda cornered the "a little strange, but in a good way" thing back in the day.

Jennifer Carpenter, the lady that played Dexter's sister on Dexter.

Andy Driver

Jennifer Garner

Oh! And you can't leave out Anne Ramsey, Mama from the Goonies.

There's other older actresses with fascinating faces from a photography/art perspective, but they don't get the kind of attention younger actresses do.

Gayle Vance, most famous for mystery men and "just junk it"

Reta Shaw! Fairly famous ages ago

A lot of actresses that played in supporting roles on tv back in the fifties and sixties were more handsome than pretty, so you got some distinct features, especially on sitcoms.

Seriously, I could keep going, there's just so many actresses that don't get leading romance roles that are superb at their jobs, but don't fit that fantasy set of features. It's this whole thing.

Anya Taylor-Joy

Tilda Swinton was the first that came to my mind.

On the black side Forest Whittaker has a pretty unique look.

Danny DeVito.

I don't know if this helps you, but in computer science there's a dataset called CelebA containing huge amounts of celebrity face photos, original and cropped with some basic attributes annotations, that is used to train various deep learning models.

Thandie Newton

Luis Guzmán

Karen Robinson - plays Ronnie in Schitt's Creek

Adam Pearson was the first that came to mind.
Having a bit more of a think about women in particular, I'd say Michaela Coel, Milly Shapiro, Liz Carr just off the top of my head, I'm sure there are more, I might add them if they come to me (keeping in mind that I'm terrible with both faces and names lol)..

On an aside - this is a great demonstration of representation (or lack thereof) and intersectionality.
While more white cis men are allowed to exist in the industry without meeting the "ideal" standard, darker skinned people (even within majority black/brown countries, colourism is still a very real problem), disabled people, trans people, and women in general but also specifically within each of the other categories, are all still held to a much higher standard and scrutiny (and of course the more of those categories you fit in to, the worse it is). And it isn't a bug of course, but a feature.

Ella Purnell from Fallout.

Rami Malek comes to mind. If I am not mistaken, he is Egyptian, so not your typical Hollywood white mail.

Matt Smith, the 11th Doctor in Doctor Who

Brock Peters from 'To Kill A Mockingbird.'

Can't think of any actor who looks like him.

You might be able to find some more unique looks by searching for terms like mixed heritage, often children with unusual combinations of ethnicities also have facial features that are not often seen in the countries where the individual ethnicities are common.

Zendaya

Rossy de Palma

my celebrity crush: Zoe Saldana. she kinda looks like an alien, but damn...she is the epitome of beauty, my Aphrodite 😍

I think Tony Cox fits the bill.